Kate Marsden was a controversial nurse who made one of the hardest journeys ever for a female across Siberia in 1891, by sledge and on horseback, sometimes at -50, searching for evidence of lepers. She fundraised for a leper colony to be built but her life was overtaken by shocking newspaper headlines that put an end to her career and sanity. Jacki has recreated her journey by public transport, found the remains of the leper colony, written a book about her, and is now involved in humanitarian work in Yakutia.